December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Endocrine And Metabolic Abnormalities In Central Serous Chorioretinopathy
Author Affiliations & Notes
  • R Haimovici
    Department of Ophthalmology
    Boston University School of Medicine Boston MA
  • S Rumelt
    Department of Ophthalmology
    Boston University School of Medicine Boston MA
  • J Melby
    Department of Medicine
    Boston University School of Medicine Boston MA
  • Footnotes
    Commercial Relationships   R. Haimovici, None; S. Rumelt, None; J. Melby, None. Grant Identification: Macula Foundation; Richard H. Chartrand Foundation; RPB; Massachusetts Lions Eye Research Fund
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 530. doi:
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      R Haimovici, S Rumelt, J Melby; Endocrine And Metabolic Abnormalities In Central Serous Chorioretinopathy . Invest. Ophthalmol. Vis. Sci. 2002;43(13):530.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To investigate and identify endocrine and metabolic abnormalities in patients with central serous chorioretinopathy (CSCR). Methods: Serum and urinary catecholamines, glucocorticoids, mineralocorticoids, serum testosterone, and thyroid stimulating hormone (TSH) function were evaluated prospectively in patients with active CSCR. Results: Fifty percent (12/24) of patients with active CSCR showed elevated 24-hour urine cortisol or tetrahydroaldosterone levels. Plasma catecholamines were elevated in 7/24 patients although 24-hour urine metanephrines were normal. Serum testosterone and TSH levels were normal in nearly all (23/24) patients. Conclusion: Many patients with CSCR have elevated 24-hour urine corticosteroids, which may contribute to the pathogenesis of the disorder. Endogenous mineralocorticoid dysfunction is a newly described feature of CSCR.

Keywords: 460 macula/fovea • 567 retinal pigment epithelium • 554 retina 
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