December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Diabetic Macular Edema: Correlation Between Microaneurysms and Retinal Thickness
Author Affiliations & Notes
  • NP Blair
    Ophthalmology & Visual Science University of Illinois Chicago IL
  • M Shahidi
    Ophthalmology & Visual Science University of Illinois Chicago IL
  • WW Lai
    Ophthalmology & Visual Science University of Illinois Chicago IL
  • R Zelkha
    Ophthalmology & Visual Science University of Illinois Chicago IL
  • Footnotes
    Commercial Relationships   N.P. Blair, None; M. Shahidi, None; W.W. Lai, None; R. Zelkha, None. Grant Identification: NIH Grant EY10314, RPB
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 537. doi:
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      NP Blair, M Shahidi, WW Lai, R Zelkha; Diabetic Macular Edema: Correlation Between Microaneurysms and Retinal Thickness . Invest. Ophthalmol. Vis. Sci. 2002;43(13):537.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Microaneurysms are commonly believed to be causally related to retinal thickening in diabetes, especially by leaking. Accordingly, laser exposures are often directed at microaneurysms to treat diabetic macular edema. We tested the hypothesis that thicker areas of retina in diabetic macular edema have more microaneurysms per unit area than less thick areas. Methods: We performed retinal thickness analysis with a prototype instrument on 10 eyes of 10 diabetics with macular edema. We compared the thickness at each 200 x 200 micrometer location in a 6 x 6 mm area of macula to corresponding locations in 22 normal eyes. The mean (SD ) age, sex (m/f), and eyes (r/l) were 51 (13) and 57 (10), 5/5 and 14/8, and 3/7 and 11/11 in the diabetics and normals, respectively. Maps of four levels of relative retinal thickness (0.70 to 1.10, 1.01 to 1.30, 1.31 to 1.50, and 1.50 to 2.00 times normal) in the diabetics were superimposed on fluorescein angiograms from the same eyes. Two graders counted the microaneurysms in zones with each thickness level. Results: The correlation between the counts by the two graders was 0.94. The means (SD) of the microaneurysms per mm2 were 1.4 (0.9), 1.5 (1.3), 1.1 (1.1), and 1.4 (2.2), respectively, in the above zones (P=0.900). Conclusion: We found no greater concentration of microaneurysms in the more edematous retinal areas in diabetic retinopathy. Some microaneurysms may not cause thickening and/or other factors may contribute to retinal thickening in diabetic retinopathy. The results may have implications on how to apply laser treatment optimally in diabetic retinopathy.

Keywords: 388 diabetic retinopathy • 430 imaging/image analysis: clinical • 432 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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