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C Garcher, P-J Pisella, P Fournier, F Malecaze, C Baudouin; Assessment of Ocular Surface Changes During Refractive Surgery . Invest. Ophthalmol. Vis. Sci. 2002;43(13):54.
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Purpose: To assess ocular surface changes during refractive surgery. Method: Routine ophthalmic examinations, corneal sensitivity measurements, Break up time and Schirmer test were performed in patients who underwent myopic LASIK or PRK treatments. Impression cytologies for HLA DR and MUC5 AC assessments were performed in the same time. These parameters were evaluated before and 3 months after refractive treatment. Results: A total of 36 eyes were included (LASIK : n : 22, PRK : n : 14). A decreased corneal sensitivity was observed after 3 months with LASIK (p<0.01) but not with PRK. Conversely, Break up time and Schirmer test were unchanged. HLA DR did not seemed to be modified by refractive surgery whereas MUC 5AC seemed to increase either with LASIK or PRK (p<0.05). Conclusion: LASIK treatment induced more ocular surface changes than PRK. These results are probably partly due to the neurotrophic damages induced by refractive surgery. However, mucus production seemed to be influenced by both methods.
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