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T Okano, K Matsuno, H Sugano, J Ochiai; Retinal Hemodynamics in Advanced Diabet Icretinopathy After Panretinal Photocoagulation . Invest. Ophthalmol. Vis. Sci. 2002;43(13):549.
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Purpose: This study was performed to reveal the therapeutic effects of panretinal photocoagulation(PRP) retardation of retinal circulation in advanced diabetic retinopathy. We investigated the effects of PRP on the velocity of retinal hemodynamics in proliferative diabetic retinopathy. Methods: The velocity of retinal circulation in diabetic eyes with advanced retinopathy was evaluated by means of rapid serial fluorescein angiopathy(FAG), employing scanning laser ophthalmoscope(SLO). FAG was conducted at the rate of 30 frames per seconds with a SLO(Rodenstok) in video-tape following injection of 5ml of 10% fluorescein sodium into the antecubital vein. Disc-to-macula transit time(DMTT) was defined as the time interval between the initial appearance of dye bolus in the central retinal artery and the moment of initial dye filling in the parafoveal capillaries. The control value was 3.7 ± 0.7 seconds(averaged by 30 eyes). The DMTT in advanced diabetic retinopathy was measured before and after PRP. Normal 30 eyes were used as control and diabetic 12 eyes with proliferative diabetic retinopathy before photocoagulation were evaluated. These diabetic subjects progressed until the stage when the PRP was necessary. They were examined to measure the DMTT before and after PRP. Results: Mean DMTT decreased from 9.4 ± 2.1 seconds before PRP to 6.5 ± 1.6 seconds after PRP in 12 diabetic eyes(p<0.05). DMTT before and after PRP was significantly longer than mean DMTT in 30 normal eyes(3.7 ± 0.7 seconds; p<0.001). The DMTT in diabetic eyes with improvement after PRP was significantly shorter than that before PRP. But the DMTT after was longer than that in normal eyes. Conclusion: Retinal hemodynamics are retarded in diabetic eyes with retinopathy. The retardation of retinal circulation in diabetic retinopathy after effective PRP improves significantly. But the value after PRP can not recover until the control level. Retinal circulation is retarded in patients with advanced diabetic retinopathy. This is partially corrected by PRP.
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