December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Plasma Nitric Oxide Levels in Diabetic Patients
Author Affiliations & Notes
  • S Igarashi
    Ophthalmology Asahikawa Medical College Asahikawa Japan
  • N Izumi
    Ophthalmology Asahikawa Medical College Asahikawa Japan
  • T Nagaoka
    Ophthalmology Asahikawa Medical College Asahikawa Japan
  • H Yokota
    Ophthalmology Asahikawa Medical College Asahikawa Japan
  • F Mori
    Ophthalmology Asahikawa Medical College Asahikawa Japan
  • A Yoshida
    Ophthalmology Asahikawa Medical College Asahikawa Japan
  • Footnotes
    Commercial Relationships   S. Igarashi, None; N. Izumi, None; T. Nagaoka, None; H. Yokota, None; F. Mori, None; A. Yoshida, None. Grant Identification: None
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 554. doi:
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      S Igarashi, N Izumi, T Nagaoka, H Yokota, F Mori, A Yoshida; Plasma Nitric Oxide Levels in Diabetic Patients . Invest. Ophthalmol. Vis. Sci. 2002;43(13):554.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Nitric oxide (NO) is a vasoactive substance produced by endothelial cells and reflects endothelial function. Recently, it is suggested that abnormal NO metabolism contributes to the development or progression of diabetic microvascular complications. We evaluated the plasma nitrate (NO3-) levels, which are the stable metabolite of NO, in patients with diabetes and controls. Methods: Plasma NO3- levels were measured in 35 patients with diabetic retinopathy (DR group; mean age, 62 years), 21 patients with non-diabetic retinopathy (non-DR group; mean age, 61 years), and 20 normal controls (control group; mean age, 61 years), using an automated sample injector connected to an automated NO detector-HPLC system (ENO-20, Eicom, Japan). We investigated the changes in the plasma NO3- levels in the three groups. Results: The plasma NO3- levels were 34.6±19.3, 60.0±56.9, and 34.4±21.5 µM in the DR group, the non-DR group, and the control group, respectively. There was a statistically significant difference between the plasma NO3- levels in the non-DR and the control groups (p<0.05), and the non-DR and the DR groups (p<0.05); however, there was no statistically significant difference between the plasma NO3- levels in the DR and control groups. Conclusions: These results suggest that plasma NO levels increase in patients with non-DR, but decrease in patients with diabetic retinopathy.

Keywords: 388 diabetic retinopathy • 491 nitric oxide • 355 clinical (human) or epidemiologic studies: risk factor assessment 
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