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DJ Galarreta, I Arranz, MJ González, RM Corrales, V Saez, A Mayo, M Calonge, JM Herreras; Comparison of Ocular Surface Alterations Induced by High and Low Water Content Hydrogel Contact Lenses . Invest. Ophthalmol. Vis. Sci. 2002;43(13):75.
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Purpose:To compare changes in ocular surface induced by contact lens wear with two different hydrogel contact lenses (HCL) (high and low water content) Methods: Twenty-six healthy myopic subjects (52 eyes) between 18 and 35 years of age who never worn contact lenses before were selected. No topical or systemic medications were allowed. Patients were randomized into two groups. Group 1: 12 patients (24 eyes) fitted with low water content (38%) HCL; group 2: 14 patients (28 eyes) fitted with high water content (66%) HCL. Double-masked follow up was performed. The variables analyzed were: modified Mc Monnies test, non invasive break up time (NIBUT), slit lamp examination (signs of blepharitis, limbal and conjunctival hyperemia, follicles, tarsal papillae, conjunctivochalasis, and corneal neovascularization), Schirmer II test, fluorescein and rose bengal stainings, lysozime and osmolarity in tear, conjunctival impression citology, ultrasound pachymetry, and Orbscan II examination. Data were collected before HCL fitting and at 1, 3 and 6 months. Results: Group 1 showed a significant alteration of the following at 6 months: presence of signs of blepharitis, corneal fluorescein and rose bengal stainings, modified Mc Monnies test, NIBUT, presence of tarsal papillae, and increased osmolarity. In group 2, only presence of tarsal papillae and increased osmolarity levels were significantly altered at month 6. Comparing results between both groups, some parameters were significantly worse in group 1: presence of signs of blepharitis, corneal fluorescein and rose bengal stainings, modified Mc Monnies test, NIBUT, presence of tarsal papillae, and increased osmolarity. Conclusion: HCL induced alterations in ocular surface as early as 6 months of wearing, more evident in low water content.
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