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PT Finger, HV Tran, R Turbin, HD Perry, R Ritch; High Frequency Ultrasound (UBM) Evaluation of CIN and Squamous Carcinoma of the Conjunctiva . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1102.
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Background: Squamous conjunctival neoplasia can be limited to the conjunctival epithelium, or penetrate into the substantia propria, cornea, sclera, eye, and orbit. Purpose: To evaluate the high-frequency ultrasound characteristics, penetration, and distribution of squamous conjunctival neoplasms. Methods: Ten patients with clinically diagnosed CIN and squamous carcinoma of the conjunctiva were evaluated by high frequency ultrasonography (20 or 50 MHz). Internal reflectivity, scleral invasion, and intraocular extension were observed. Treatment was performed after ultrasound evaluation. This involved local resection with adjuvant cryotherapy, local resection after topical mitomycin chemoreduction, local resection followed by external beam radiation therapy, and (in one case) orbital exenteration. Results: Ultrasound findings included: plaque-like lesions attached to the eye-wall. The tumor stroma was low reflective (unless imaged within the eye). Ultrasound evaluations clearly demonstrated the tumors deep (episcleral, epicorneal) margins. The interface between the tumor, the cornea and the sclera were clearly visible. Scleral, uveal and anterior chamber tumor invasion were demonstrated. In one case, tumor-related blunting of the anterior chamber angle was noted. Conclusion: High-frequency ultrasonography can be used to determine the presence of intraocular extension of squamous conjunctival neoplasia. Low internal reflectivity was characteristic of the tumors stroma. Clearly, ultrasound was helpful in pre-operative evaluation of patients with squamous conjunctival neoplasia.
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