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IC Pereira, SA Schellini, ME A Marques, C Pelison, CR Padovani; Colagenase Ointment In The Healing Of A Radiofrequency Abrasive Wound . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1106.
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Purpose:The radiofrequency abrasion is suggested to treat periorbital superficial wrinkles in select patients. The purpose of this study is to determine the role of the colagenase ointment in the epithelial healing of an abrasive wound produced by a radiofrequency system. Methods:An abrasive wound was surgically produced by a radiofrequency system in the dorsal midline of 30 rats. The animals were divided into 2 groups (3 rats/group): one group was treated with saline solution (G1) and the other with colagenase ointment, 2 times daily (G2) (Iruxol Mono - Knoll). The animals were sacrificed at 5 experimental moments: 1 (M1), 7 (M2), 15 (M3), 30 (M4) and 60 (M5) postoperative days. The wound and the surrounding tissue were assessed for macroscopic and histopathological evaluation and the epidermis and dermis thickness were measured using an image analysis system. The results were submitted to statistical analysis. Results:Macroscopic evaluation showed a statisticaly significant delay in the healing process and a sanguinolent crust formation involving the wound in G1 than in G2 at M1 and M2. The delayed wound healing process in G1 was also observed in the histopathological evaluation as the presence of a fibrinoid crust and a thick layer of inflammatory cell infiltrate surrounding the wound at M1 until M3. Statistically significant differences of wound healing between the 2 groups at M4 and M5 were not observed. Morphometric evaluation showed a thicker epidermis layer and a thinner dermis layer in G1 at the first experimental moments, but statistically significant differences were not observed at the final moments. Conclusion:The colagenase ointment revealed to accelerate the wound healing process after an abrasive wound produced by a radiofrequency system.
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