Purchase this article with an account.
WH Seiple, C Clemens, K Holopigian, V Greenstein, R Carr; Relationships Among Luminance, Acuity, Contrast, and Electrophysiological Perimetry in Patients with Retinitis Pigmentosa . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1168.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare a standard clinical measure of visual field sensitivity (Humphrey Visual Field Analyzer) to perimetry, measured using higher-level psychophysical tasks (acuity and contrast sensitivity), and to perimetry measured with the multifocal ERG (mfERG) technique in patients with retinitis pigmentosa (RP). Methods: Luminance sensitivity, letter acuity, and grating contrast sensitivity were measured at 13 locations within the central 10 degrees. Targets were presented along the horizontal and vertical meridians on a CRT display (mean luminance 150 cd/m2) for a duration of 375 msec. mfERGs were recorded using a standard protocol and a 103-hexagon array. Humphrey visual field thresholds were also measured at the same retinal locations. Data from a group of six patients with RP were compared to the results from six age-similar control subjects. For the patients, log losses in sensitivity from the average control values at the corresponding locations were calculated. Results: For this group of patients with RP, sensitivity on all of the tasks decreased as a function of eccentricity, as expected. Overall, luminance sensitivity and contrast sensitivity showed the least sensitivity loss (median = 0.18 and 0.17 log units, respectively). The mfERG amplitude measure was most affected (median = 0.52 log units) and spatial resolution showed an intermediate amount of loss (0.25 log units). Conclusion: These results suggest that perimetric measures of acuity and contrast sensitivity may prove to be useful additions to standard clinical field and mfERG measures for following disease progression.
This PDF is available to Subscribers Only