December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Prospective Case-Control Study of Infrared Fundus Imaging in Subjects at High and Low Genetic Risk for AMD
Author Affiliations & Notes
  • SN Appa
    Ophthalmology University of Texas Southwestern Medical Center Dallas TX
  • AN Safar
    Ophthalmology University of Arkansas Little Rock AR
  • W Anderson
    Ophthalmology University of Texas Southwestern Medical Center Dallas TX
  • AO Edwards
    Ophthalmology University of Texas Southwestern Medical Center Dallas TX
  • Footnotes
    Commercial Relationships   S.N. Appa, None; A.N. Safar, None; W. Anderson, None; A.O. Edwards, None. Grant Identification: Support: Research to Prevent Blindness
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1206. doi:
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    • Get Citation

      SN Appa, AN Safar, W Anderson, AO Edwards; Prospective Case-Control Study of Infrared Fundus Imaging in Subjects at High and Low Genetic Risk for AMD . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1206.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To determine the type and frequency of infrared (IR) reflectance abnormalities in subjects with high and low genetic risk for AMD. Methods: Stereoscopic color and IR fundus imaging were prospectively performed on 23 descendents of patients with AMD and an affected first-degree relative and 19 subjects without a family history of AMD. All subjects were between age 40 to 55 years. Results: Drusen and IR reflectance abnormalities were frequent in both groups, but more common in high-risk subjects. Ten subjects (43.5%) in the high-risk group compared to one (5.3%) in the control group had greater than 20 infrared reflectance abnormalities (p<0.03). Conclusion: Infrared imaging may be useful in identifying young individuals at risk for developing AMD.

Keywords: 308 age-related macular degeneration • 430 imaging/image analysis: clinical • 391 drusen 
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