December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Retinal Angiopathy and Polypoidal Choroidal Vasculopathy
Author Affiliations & Notes
  • DL Costa
    LuEsther T Mertz Retinal Research Center Manhattan Eye Ear and Throat Hospital New York NY
  • T Iida
    LuEsther T Mertz Retinal Research Center Manhattan Eye Ear and Throat Hospital New York NY
  • B Freund
    LuEsther T Mertz Retinal Research Center Manhattan Eye Ear and Throat Hospital New York NY
  • SJ Huang
    LuEsther T Mertz Retinal Research Center Manhattan Eye Ear and Throat Hospital New York NY
  • AP Ciardella
    LuEsther T Mertz Retinal Research Center Manhattan Eye Ear and Throat Hospital New York NY
  • I Donsoff
    LuEsther T Mertz Retinal Research Center Manhattan Eye Ear and Throat Hospital New York NY
  • BM Golub
    Long Island Vitreo-Retina Consultants Great Neck NY
  • LA Yannuzzi
    LuEsther T Mertz Retinal Research Center Manhattan Eye Ear and Throat Hospital New York NY
  • Footnotes
    Commercial Relationships   D.L. Costa, None; T. Iida, None; B. Freund, None; S.J. Huang, None; A.P. Ciardella, None; I. Donsoff, None; B.M. Golub, None; L.A. Yannuzzi, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1234. doi:
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    • Get Citation

      DL Costa, T Iida, B Freund, SJ Huang, AP Ciardella, I Donsoff, BM Golub, LA Yannuzzi; Retinal Angiopathy and Polypoidal Choroidal Vasculopathy . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1234.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To describe the clinical and angiographic features of patients with polypoidal choroidal vasculopathy, exudative detachment of the macula and an associated retinal microangiopathy. Method: A case series. Results: Four patients with chronic exudative detachment of the macula with a variable degree of lipid deposition are described. The retina in the detached area, but not beyond, was noted to have a microangiopathy. There was capillary telangiectasia, microaneurysm formation, patchy non-perfusion, and intraretinal leakage. On each patient there were no other retinal vascular changes in the fundus of either eye. The fluorescein angiogram revealed subretinal leakage suspicious of occult choroidal neovascularization. The indocyanine green angiogram demonstrated the presence of underlying polypoidal choroidal neovascularization, accounting for the exudative detachment. Following photocoagulation, the retinal angiopathy improved, but not completely. Conclusion: Retinal microangiopathy may occur in a chronic macular detachment secondary to polypoidal choroidal neovascularization. The development of these secondary retinal changes is not clearly understood; however, hypoxia from the chronic detachment, a neurotoxic effect from the lipid deposition, or a biochemically induced microvascular abnormality from secretion of vasogenic mediators are possible mechanisms. Indocyanine green angiography is helpful in making a definitive diagnosis. Clinicians should be aware that a retinal microangiopathy might occur in such eyes so that the proper diagnosis can be made and appropriate treatment administered.

Keywords: 346 choroid: neovascularization • 308 age-related macular degeneration • 563 retinal detachment 
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