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X Xiao, Q Zhang, L Guo, X Jia, X Guo, S Li; Low-Tension Glaucoma-like Phenotype in a LHON Patient with Mitochondrial DNA 11778 Mutation . Invest. Ophthalmol. Vis. Sci. 2002;43(13):815.
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Purpose: To document low-tension glaucoma-like ocular changes in a patient with Leber's hereditary optic neuropathy (LHON) and and mitochondrial DNA (mtDNA) 11778 mutation. Methods: Examination of intraocular pressure (IOP), visual field, optical coherence tomography (OCT), Heidelberg retina tomograph (HRT), CT scan of brain, and mtDNA mutational screening was conducted in the patient. Results: Ocular examination of IOP, ophthalmoscope, visual field, OCT and HRT displayed a phenotype of low tension glaucoma in the patient. CT scan showed no abnormality of the optical canal, chiasm and brain. Gene analysis of the patient revealed a homozygous mtDNA 11778 mutation, which implied a disease of Leber's hereditary optic neuropathy (LHON). Conclusion: LHON may rarely have a manifestion similar to low-tension glaucoma.
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