December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Mutations of the Zinc Finger Protein 161 Gene in Chinese With or Without High Myopia
Author Affiliations & Notes
  • G Wang
    Ocular Genetics & Molec Bio Zhongshan Ophthalmic Center Guangdong China
  • JZ Li
    Department of Ophthalmolgy The people\#8217;s Hospital of Enshi Autonomous Prefecture Enshi Hubei China
  • FS Zhang
    Chaoju Eye Hospital Baotou Inner Mongolia China
  • T Li
    Department of Ophthalmolgy The people\#8217;s Hospital of Enshi Autonomous Prefecture Enshi Hubei China
  • QJ Zhang
    Guangdong China
  • XS Xiao
    Guangdong China
  • SQ Li
    Guangdong China
  • XY Jia
    Guangdong China
  • L Guo
    Guangdong China
  • XM Guo
    Guangdong China
  • Footnotes
    Commercial Relationships   G. Wang, None; J.Z. Li, None; F.S. Zhang, None; T. Li, None; Q.J. Zhang , None; X.S. Xiao , None; S.Q. Li , None; X.Y. Jia , None; L. Guo , None; X.M. Guo , None. Grant Identification: Support:863 Hi-tech Plan of China(Z19-01-04-02,QZ)
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 823. doi:
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    • Get Citation

      G Wang, JZ Li, FS Zhang, T Li, QJ Zhang, XS Xiao, SQ Li, XY Jia, L Guo, XM Guo; Mutations of the Zinc Finger Protein 161 Gene in Chinese With or Without High Myopia . Invest. Ophthalmol. Vis. Sci. 2002;43(13):823.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Zinc finger protein has been shown to related with experimental myopia. A zinc finger protein (ZFP161, omim602126) is located on 18p11.31 where a locus for high myopia (MYP2) has been determined but causative gene has not yet been identified. This study was to search for genes responsible for MYP2 and to analyze the sequence variation of ZFP161 in probands with high myopia. Methods: Genomic DNA was prepared from probands of 211 family with high myopia (<=-6.0 diopters ) and 116 unrelated persons without high myopia. The coding regions of ZFP161 were analyzed by using PCR- heteroduplex -SSCP analysis and sequencing. Results: Variations at codon56GCC→GCA (Ala56Ala) and IVS1-58∼59 ATins were detected. The former one is a nonsense heterozygous mutation identified in 5 of the 211 probands with high myopia and 3 of the 116 individuals without high myopia. The other is a heterozygous AT insertion in the intron but none of the 116 controls. Family analysis showed this mutation does not present in her parents who have no high myopia. Conclusion: No evidence shows that the ZFP161 gene is responsible for high myopia.

Keywords: 481 myopia • 480 mutations • 420 genetics 
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