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S Binder, I Krebs, H Feichtinger, A Abri, R Hilgers, L Kellner, C Jahn, U Stolba, A Assadoullina, B Stanzel; Outcome after Transplantation of Autologous Retinal Pigment Epithelium in Eyes with Foveal CNV due to AMD - A Non Randomized Trial . Invest. Ophthalmol. Vis. Sci. 2002;43(13):924.
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Purpose: Clinical , Electrophysiological (MERG) and Optical Coherence Tomography(OCT) results of a consecutive series of 50 eyes with age related macular degeneration (AMD) and foveal choroidal neovascularisation (fCNV)- not eligible for photodynamic therapy (PDT)- in which subretinal surgery was combined with simultaneous transplantation of autologous retinal pigment epithelial cells. Methods: In a non randomized clinical trial 50 eyes of 50 patients with AMD underwent subretinal surgery because of fCNV with simultaneous transplantation of autologous RPE, a method recently described by us in a pilot study. At 3- month intervals examinations were performed including best corrected visual acuity, multifocal ERG`s and OCT.7 eyes treated by surgical membrane excision alone and served as controls. Results: After a median observation time of 14 months (range 12 to 18 months) visual acuity was improved two or more lines in 44% ( 19 pats.), remained the same +/- one line in 46% (23 pats.) and decreased 2 or more lines in 10% (5 pats.). Multifocal ERG`s showed the highest values 3 months postoperatively, and remained higher for up to one year when compared to preoperative values. OCT examinations showed thinning of retinal layers in most of the cases. In one eye a recurrent extrafoveal CNV was observed after 6 months. Conclusion: The results of this trial suggest that autologous transplantation of RPE combined with subretinal surgery might be a reasonable treatment option for patients with fCNV secondary to AMD.
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