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DF Sweeney, J Stern, T Naduvilath, BA Holden; Inflammatory adverse event rates over 3 years with Silicone Hydrogel lenses . Invest. Ophthalmol. Vis. Sci. 2002;43(13):976.
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Purpose:Reducing adverse events remains one of the key challengesfor trouble-free extended wear. We report the yearly incidenceand recurrence of significant inflammatory events with 30 nightscontinuous wear.Methods:In a prospective 36 month clinicaltrial, 116 patients wore bilateral high Dk lenses on a 30NEWschedule. Patients were reviewed at one week, one month, threemonths and then at three monthly intervals until 36MEW. Patientswere assessed at unscheduled visits when they presented to theclinic with unusual signs or symptoms. Significant inflammatoryadverse events were classified as Contact Lens Peripheral Ulcer(CLPU), Contact Lens induced Acute Red Eye (CLARE) and InfiltrativeKeratitis (IK). The incidence per eye year (%) was determinedand differences between the years were assessed using FishersExact test.Results:See attached tableConclusion:The incidenceof CLPU and IK are constant across the three years of this study.The incidence of CLARE increased between the second and thirdyear of the study, however the rate across the study is low.There is the chance of recurrence of each of the inflammatoryevents reported, particularly CLARE. The incidence and recurrenceshould be considered with patient management.
Indicence of firstevents View OriginalDownload SlideView OriginalDownload Slide Recurrencerates View OriginalDownload SlideView OriginalDownload Slide>
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