December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Altered Expression of TrkB and TrkC Nerve Growth Factor Receptors in the Lateral Geniculate Nucleus in Glaucoma
Author Affiliations & Notes
  • Y Yucel
    Ophthalmology Laboratory Medicine & Pathobiology St Michael's Hospital University of Toronto Toronto ON Canada
  • J Yeung
    Ophthalmology Laboratory Medicine & Pathobiology St Michael's Hospital University of Toronto Toronto ON Canada
  • Q Zhang
    Ophthalmology Laboratory Medicine & Pathobiology St Michael's Hospital University of Toronto Toronto ON Canada
  • RN Weinreb
    Glaucoma Center University of California San Diego San Diego CA
  • PL Kaufman
    Ophthalmology and Visual Sciences University of Wisconsin Madison Madison WI
  • N Gupta
    Ophthalmology Laboratory Medicine & Pathobiology St Michael's Hospital University of Toronto Toronto ON Canada
  • Footnotes
    Commercial Relationships   Y. Yucel, None; J. Yeung, None; Q. Zhang, None; R.N. Weinreb, None; P.L. Kaufman, None; N. Gupta, None. Grant Identification: Support:EA Baker Found.CNIB(NG;YY),Glaucoma Found.(YY),J Drown Found.(RNW),NEI(EY02698,PLK),RPB(PLK)
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 987. doi:
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    • Get Citation

      Y Yucel, J Yeung, Q Zhang, RN Weinreb, PL Kaufman, N Gupta; Altered Expression of TrkB and TrkC Nerve Growth Factor Receptors in the Lateral Geniculate Nucleus in Glaucoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):987.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To determine whether high affinity receptors for brain derived neurotrophic factor (TrkB), neurotrophin 4 (TrkB), and for neurotrophin 3 (TrkC), are expressed in the LGN and whether their expression is altered in glaucoma. Methods:The LGNs from brains of cynomolgus monkeys (n=4) with experimentally induced glaucoma in the right eye and of control monkeys (n=5) were studied. Immunocytochemistry was used to detect TrkB and TrkC in LGN sections. Similar conditions of fixation, tissue processing, staining, and examination were used in both groups. Results:In the normal LGN, distinct immunoreactivity for both TrkB and TrkC was observed in all 6 layers. Magnocellular layers (1,2) showed stronger immunoreactivity for TrkB and TrkC compared to the parvocellular layers (3-6). Similar findings were observed in experimental glaucoma with 17% and 29% optic nerve fiber loss. However, in glaucoma with 61% and 100% optic nerve fiber loss, LGN layers connected to the glaucomatous eye showed a strong decrease in TrkB and TrkC expression compared to LGN layers connected to the fellow eye and to the corresponding layers in controls. Conclusion:: The normal primate LGN expresses TrkB and TrkC neurotrophin receptors. The finding of a significant decrease in their expression in moderate to severe glaucoma may be relevant to understanding the role played by neurotrophins in glaucomatous damage.

Keywords: 423 growth factors/growth factor receptors • 598 thalamus/lateral geniculate nucleus • 506 pathology: experimental 
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