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Y Yucel, J Yeung, Q Zhang, RN Weinreb, PL Kaufman, N Gupta; Altered Expression of TrkB and TrkC Nerve Growth Factor Receptors in the Lateral Geniculate Nucleus in Glaucoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):987.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To determine whether high affinity receptors for brain derived neurotrophic factor (TrkB), neurotrophin 4 (TrkB), and for neurotrophin 3 (TrkC), are expressed in the LGN and whether their expression is altered in glaucoma. Methods:The LGNs from brains of cynomolgus monkeys (n=4) with experimentally induced glaucoma in the right eye and of control monkeys (n=5) were studied. Immunocytochemistry was used to detect TrkB and TrkC in LGN sections. Similar conditions of fixation, tissue processing, staining, and examination were used in both groups. Results:In the normal LGN, distinct immunoreactivity for both TrkB and TrkC was observed in all 6 layers. Magnocellular layers (1,2) showed stronger immunoreactivity for TrkB and TrkC compared to the parvocellular layers (3-6). Similar findings were observed in experimental glaucoma with 17% and 29% optic nerve fiber loss. However, in glaucoma with 61% and 100% optic nerve fiber loss, LGN layers connected to the glaucomatous eye showed a strong decrease in TrkB and TrkC expression compared to LGN layers connected to the fellow eye and to the corresponding layers in controls. Conclusion:: The normal primate LGN expresses TrkB and TrkC neurotrophin receptors. The finding of a significant decrease in their expression in moderate to severe glaucoma may be relevant to understanding the role played by neurotrophins in glaucomatous damage.
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