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S Thimmappa, D Ritterband, M Shah, A Farquahar, J Li, J Seedor; Antibiotic Susceptibilities of Ocular Isolates to Moxifloxacin a Fourth Generation Fluoroquinolone . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1582.
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Purpose:To assess the in-vitro susceptibility of ocular bacterial isolates to moxifloxacin, a new antibiotic from the fluoroquinolone class. Methods:100 ocular isolates archived at the NY Eye and Ear Infirmary from corneal ulcers or cases of endophthalmitis were tested for in vitro susceptibility to moxifloxacin, ciprofloxacin, levofloxacin and ofloxacin using E-test (AB Biodisc) antimicrobial gradient strips. Results:The order of susceptibility for gram-positive organisms was moxifloxacin ≷ levofloxacin ≷ ciprofloxacin=ofloxacin. The order of susceptibility for gram- negative organisms was moxifloxacin=levofloxacin=ciprofloxacin ≷ ofloxacin. 13 Pseudomonas aeruginosa microbes resistant to 2nd generation fluoroquinolones (ciprofloxacin and ofloxacin) were also resistant to levofloxacin and moxifloxacin. Conclusion:Moxifloxacin, a 4th generation fluoroquinolone, has a greater in-vitro efficacy against our archived gram-positive organisms and equal efficacy against our gram-negative organisms. Second generation fluoroquinolone resistant Pseudomonas species were also resistant to levofloxacin and moxifloxacin.
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