December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Antibiotic Susceptibilities of Ocular Isolates to Moxifloxacin a Fourth Generation Fluoroquinolone
Author Affiliations & Notes
  • S Thimmappa
    Ophthalmology New York Eye and Ear Infirmary New York NY
  • D Ritterband
    Ophthalmology New York Eye and Ear Infirmary New York NY
  • M Shah
    Ophthalmology New York Eye and Ear Infirmary New York NY
  • A Farquahar
    Ophthalmology New York Eye and Ear Infirmary New York NY
  • J Li
    Ophthalmology New York Eye and Ear Infirmary New York NY
  • J Seedor
    Ophthalmology New York Eye and Ear Infirmary New York NY
  • Footnotes
    Commercial Relationships   S. Thimmappa, None; D. Ritterband, None; M. Shah, None; A. Farquahar, None; J. Li, None; J. Seedor, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1582. doi:
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    • Get Citation

      S Thimmappa, D Ritterband, M Shah, A Farquahar, J Li, J Seedor; Antibiotic Susceptibilities of Ocular Isolates to Moxifloxacin a Fourth Generation Fluoroquinolone . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1582.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To assess the in-vitro susceptibility of ocular bacterial isolates to moxifloxacin, a new antibiotic from the fluoroquinolone class. Methods:100 ocular isolates archived at the NY Eye and Ear Infirmary from corneal ulcers or cases of endophthalmitis were tested for in vitro susceptibility to moxifloxacin, ciprofloxacin, levofloxacin and ofloxacin using E-test (AB Biodisc) antimicrobial gradient strips. Results:The order of susceptibility for gram-positive organisms was moxifloxacin ≷ levofloxacin ≷ ciprofloxacin=ofloxacin. The order of susceptibility for gram- negative organisms was moxifloxacin=levofloxacin=ciprofloxacin ≷ ofloxacin. 13 Pseudomonas aeruginosa microbes resistant to 2nd generation fluoroquinolones (ciprofloxacin and ofloxacin) were also resistant to levofloxacin and moxifloxacin. Conclusion:Moxifloxacin, a 4th generation fluoroquinolone, has a greater in-vitro efficacy against our archived gram-positive organisms and equal efficacy against our gram-negative organisms. Second generation fluoroquinolone resistant Pseudomonas species were also resistant to levofloxacin and moxifloxacin.

Keywords: 319 antibiotics/antifungals/antiparasitics • 468 microbial pathogenesis: clinical studies • 358 clinical laboratory testing 
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