December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Specular Microscopy of Patients with Ankylosing Spondylitis and Bacterial Culture of Aqueous Humor
Author Affiliations & Notes
  • A Lavalle
    Uveitis Hosp Nuestra Senora De La Luz Mexico City Mexico
  • E Contreras
    Uveitis Hosp Nuestra Senora De La Luz Mexico City Mexico
  • Footnotes
    Commercial Relationships   A. Lavalle, None; E. Contreras, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1592. doi:
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      A Lavalle, E Contreras; Specular Microscopy of Patients with Ankylosing Spondylitis and Bacterial Culture of Aqueous Humor . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1592.

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Abstract

Abstract: : Purpose: To determine the endothelial damage due to chronic inflammation in ankylosing spondylitis (AE) and establish an endothelial control before anterior chamber paracenthesis for bacterial culture. Methods: Endothelial specular microscopy (Topcon) of eight eyes with at least one episode of uveitis secondary to AE. Pachimetry, cellular count, pleomorphism and polymegatism were analyzed. The cellular count was obtained by using the grill method, counting the number of endothelial cells in one quadrant of the grill and multiplying the result by 200. Anterior chamber paracenthesis of eight eyes in order to obtain 100 microliters of aqueous humor and cultivate it in agar for 48 hours at 30 C in order to find bacteria (Salmonella, Chlamydia, Yersinia). Results: Eight patients (6 masculine, 2 feminine) with mean age of 41.8 years and with uveitis secondary to AE showed no direct relation between the number of episodes of anterior uveitis and the endothelial damage in the specular microscopy; pleomorphism and polymegatism did have a direct relation with hexagonality, and guttate were found even in the first episode of anterior uveitis in a patient of 12 years old. The guttate did not have a direct relation with the number of episodes of anterior uveitis in this patients. All pachimetry studies were within normal range. All bacterial cultures in agar were negative. Conclusion: The number of episodes of anterior uveitis does not determine the degree of endothelial lesion; this is mainly caused by the intensity of the inflammatory reaction, the prompt initiation of treatment, the toxicity of steroids drops and/or vehicles, and probably the idiosyncrasy of each patient. The fact that the cultures were negative implies that: the sterile technique for the anterior chamber paracenthesis was adequate;and, that there are no complete bacteria or functional bacteria in the aqueous humor in AE.

Keywords: 324 aqueous • 353 clinical (human) or epidemiologic studies: outcomes/complications • 611 uvea 
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