December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Vascular Endothelial Growth Factor (VEGF) In Aqueous Humor: Prognostic Factor In Uveal Melanoma
Author Affiliations & Notes
  • MJ Jager
    LUMC Leiden Netherlands
    Ophthalmology
  • CJ M Krose
    LUMC Leiden Netherlands
    Ophthalmology
  • W Zuidervaart
    LUMC Leiden Netherlands
    Ophthalmology
  • P Eilers
    Medical Statistics
    LUMC Leiden Netherlands
  • SR Boyd
    St Michael's Hospital Toronto ON Canada
  • G Van der Pluijm
    Endocrinology
    LUMC Leiden Netherlands
  • JE E Keunen
    LUMC Leiden Netherlands
    Ophthalmology
  • D De Wolff-Rouendaal
    LUMC Leiden Netherlands
    Ophthalmology
  • HM H Hurks
    LUMC Leiden Netherlands
    Ophthalmology
  • Footnotes
    Commercial Relationships   M.J. Jager, None; C.J.M. Krose, None; W. Zuidervaart, None; P. Eilers, None; S.R. Boyd, None; G. Van der Pluijm, None; J.E.E. Keunen, None; D. De Wolff-Rouendaal, None; H.M.H. Hurks, None. Grant Identification: Dutch Cancer Society
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 1829. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      MJ Jager, CJ M Krose, W Zuidervaart, P Eilers, SR Boyd, G Van der Pluijm, JE E Keunen, D De Wolff-Rouendaal, HM H Hurks; Vascular Endothelial Growth Factor (VEGF) In Aqueous Humor: Prognostic Factor In Uveal Melanoma . Invest. Ophthalmol. Vis. Sci. 2002;43(13):1829.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To investigate the prognostic significance of the vascular endothelial growth factor (VEGF) level in aqueous humor of uveal melanoma patients. VEGF is an important stimulator of tumor angiogenesis. Methods: VEGF concentrations were determined in aqueous humor samples of 74 uveal melanoma patients using a commercial ELISA kit obtained from Biosource. Aqueous humor was collected immediately after enucleation and stored at -80 °C until use. The results were compared to patient survival and clinical and histopathological tumor parameters. Follow-up time was 1 to 9 years. Results: The VEGF concentration in aqueous humor varied substantially, ranging from <4 to 1979 pg/ml with a mean concentration of 192 pg/ml. High VEGF concentration was significantly correlated with a large tumor diameter (p<0.005) and prominence (p<0.001) and seemed to be associated with the presence of epithelial cells within the tumor (p<0.07). VEGF level also was significantly correlated with patient survival (Cox Proportional Hazard p<0.026). Conclusion:The concentration of VEGF in the aqueous humor was significantly correlated with patient survival and therefore can be regarded as a prognostic factor in human uveal melanoma.

Keywords: 464 melanoma • 324 aqueous 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×