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CS Chen, DC Hood, X Zhang, EZ Karam, JM Liebmann, P Thienprasiddhi, R Ritch; Repeat Reliability of the Multifocal Visual Evoked Potential in Normal and Glaucomatous Eyes . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2135.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the repeat reliability of the multifocal visual evoked potential (mfVEP). Methods: 15 subjects (mean age 32+/-12 yrs) with no known visual system abnormalities participated in this study. Pattern-reversed mfVEPs were recorded on two separate days, using a 60-sector stimulus array (VERIS, EDI). The records were amplified with cutoffs at 3 and 100 Hz and filtered offline with a FFT lowpass filter (35 Hz). Within a single session, two 7-minute recordings were obtained for each eye. The amplitude of each response was obtained using a root mean square measure (RMS). The VEP ratio [10*log (RMS day 1 / RMS day 2)] provided a measure of the reproducibility of an individual response. The standard deviation of the VEP ratio was calculated for the 60 traces of each eye. The same calculations were performed for Run 1 compared to Run 2 within a day and Run 1 (Run 2) compared to Run 1 (Run 2) across days. A group of 10 glaucoma patients were analyzed in the same way. Results: For the 1800 VEP ratio values (60 traces X 15 subjects X 2 eyes), the r value of the RMS amplitude on day 1 versus the RMS amplitude on day 2 was 0.85. The mean standard deviation (sd) of the VEP ratio of all subjects was 1.63 dB for these 14 min. records. To better understand the sources of variability in the mfVEP, the variation across days were compared to the variation within a day. On average for the 7 min. records, recording across days, as opposed to within a day, increased the sd to 1.77 dB from 1.53 dB. The r value within a day (r =0.87) was larger than across days (r =0.80). Similar results were found for the patient group. The patients' mean sd was 1.75 dB with an overall r value of 0.82. Conclusions: Provided electrodes were placed in the same location, then the two day repeat reliability was close to that obtained within a single session. The two day reliability (∼1.7dB) was lower than that of the Humphrey 24-2 visual field (∼3dB)  but higher than previously reported (n=5) . Whether the mfVEP is superior in detecting change in patients with glaucoma remains to be tested. 1. Johnson & Spry, ARVO, 1999 2. Klistorner & Graham, Ophthal, 2000.
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