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LJ Velazquez-Estades, JS Schuman; Correlation of Frequency Doubling Technology Perimetry and OCT Nerve Fiber Layer Thickness Measurements . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2168.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the relationship between visual function determined by frequency doubling technology (FDT) and structure evaluated by optical coherence tomography (OCT). Methods: In a cross-sectional study, one eye of 191 patients (OS) was examined with the FDT full-threshold N-30 program and OCT (both from Carl Zeiss Ophthalmic Systems, Dublin, CA). Nerve fiber layer (NFL) thickness was assessed with OCT. FDT perimetry measures included the global indices Mean Deviation (MD) and Pattern Standard Deviation (PSD) as well as FDT scores assigned to the abnormal points in the total deviation plot. The functional and structural parameters obtained from FDT and OCT, respectively, were compared with a Pearson correlation and a partial correlation adjusting for age. Results: In eyes with inferior FDT defects (n=20), both total and inferior hemifield FDT scores correlated with OCT superior hemifield mean NFL thickness (r= -0.57, p= 0.011, and r= -0.56, p= 0.013, respectively). Also, in the same group of eyes, MD correlated with mean NFL thickness, although this did not achieve statistical significance (r= 0.41, p= 0.078). In eyes with FDT defects in both hemifields (n=55), PSD significantly correlated with OCT superior hemifield mean NFL thickness (r= -0.32, p= 0.018). Conclusions: There is a significant association between FDT functional and OCT structural measures.
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