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S Kobayakawa, T Tochikubo, Y Katayama, H Watanabe; The Penetration of Levofloxacin into Human Aqueous Humor . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2321.
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Purpose: This study was designed to measure the concentration of levofloxacin (LVFX) in aqueous humor after topical and oral administration in 101 patients undergoing cataract extraction. Method: In Group 1(N=32), 0.5% LVFX eyedrops were topically instilled five times every 30 minutes for 2 hours before the surgery. In Group 2(N=35), the patients received a single oral dose of 200 mg LVFX two hours before surgery. In Group 3(N=34), the patients received total 600mg LVFX (two 100-mg tablets, administered 18, 6, and 2 hours preceding surgery) before surgery. Aqueous humor ( 0.1ml-0.15ml) were collected before the anterior capsulotomy of each case from the cornea side port, and concentration of LVFX in aqueous humor were measured by the high performance liquid chromatograhy method (HPLC). Results: LVFX concentration in the aqueous humor of group 1 (instillation ) is 0.69±0.37µg/ml, and group 2 (oral administration 1 time ) were 0.42±0.19µg/ml, group 3 (oral administration 3 times) were 1.30±0.53µg/ml. There was a significant difference between Group 3 and Group 1,2 (p<0.0001). Conclusion: As a result, orally applied 600mg LVFX achieved a significant aqueous concentration. The aqueous humor levels of 600mg LVFX after oral route exceed the minimum inhibitory concentrations for certain bacterial species that frequently cause intraocular infection.
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