December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Intravitreal Triamcinolone Injection for the Treatment of Occult Choroidal Neovascularization associated with Age-related Macular Degeneration
Author Affiliations & Notes
  • DB Roth
    Retina Vitreous Center Robert Wood Johnson Medical School New Brunswick NJ
  • M Spirn
    Retina Vitreous Center Robert Wood Johnson Medical School New Brunswick NJ
  • DL Yarian
    Retina Vitreous Center Robert Wood Johnson Medical School New Brunswick NJ
  • SN Green
    Retina Vitreous Center Robert Wood Johnson Medical School New Brunswick NJ
  • SR Leff
    Retina Vitreous Center Robert Wood Johnson Medical School New Brunswick NJ
  • ES Friedman
    Retina Vitreous Center Robert Wood Johnson Medical School New Brunswick NJ
  • BJ Keyser
    Retina Vitreous Center Robert Wood Johnson Medical School New Brunswick NJ
  • MH Wheatley
    Retina Vitreous Center Robert Wood Johnson Medical School New Brunswick NJ
  • Footnotes
    Commercial Relationships   D.B. Roth, None; M. Spirn, None; D.L. Yarian, None; S.N. Green, None; S.R. Leff, None; E.S. Friedman, None; B.J. Keyser, None; M.H. Wheatley, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2500. doi:
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    • Get Citation

      DB Roth, M Spirn, DL Yarian, SN Green, SR Leff, ES Friedman, BJ Keyser, MH Wheatley; Intravitreal Triamcinolone Injection for the Treatment of Occult Choroidal Neovascularization associated with Age-related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2500.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To study the effect of intravitreal injection of triamcinolone as treatment for occult subfoveal choroidal neovascularization associated with age-related macular degeneration (ARMD). Method: Eight eyes of seven patients with occult choroidal neovascularization associated with ARMD were treated. The visual acuity before treatment ranged from 20/80 to 4/200. All patients were evaluated with pre-treatment fluorecein angiography (FA). The size of choroidal neovascularization on FA ranged from 2.5 mm to 7.0 mm in greatest linear diameter. Three eyes had received prior laser photocoagulation before triamcinolone injection. Treatment consisted of a single intravitreal injection of 4 mg of triamcinolone through the pars plana under sterile conditions. A paracentesis was performed if the intraocular pressure was above 40 mm Hg after injection. Several patients required repeat trimacinolone injections over follow-up for persistent or recurrent leakage on fluorescein angiography. Results: None of the patients experienced visual loss over the initial follow-up period. Three eyes experienced an improvement of 3 or more lines of Snellen visual acuity. A stabilization or reduction of subretinal fluid was seen in all patients. Conclusion: Intravitreal injection of triamcinolone appears to be an effective treatment modality for occult choroidal neovascularization in patients with ARMD. Repeat injections may be necessary to address persistent or recurrent choroidal neovascular leakage. The lasting effect of this treatment needs further study with longer follow-up.

Keywords: 308 age-related macular degeneration • 346 choroid: neovascularization • 357 clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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