December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Fundus Autofluorescence Imaging Compared With Different Confocal Scanning Laser Ophthalmoscopes
Author Affiliations & Notes
  • C Bellmann
    Institute of Ophthalmology and Moorfields Eye Hospital London United Kingdom
  • GS Rubin
    Institute of Ophthalmology London United Kingdom
  • SA Kabanarou
    Institute of Ophthalmology and Moorfields Eye Hospital London United Kingdom
  • AC Bird
    Institute of Ophthalmology and Moorfields Eye Hospital London United Kingdom
  • FW Fitzke
    Institute of Ophthalmology London United Kingdom
  • Footnotes
    Commercial Relationships   C. Bellmann, None; G.S. Rubin, None; S.A. Kabanarou, None; A.C. Bird, None; F.W. Fitzke, None. Grant Identification: European Commission QLK6-CT-2000-51262, Marie Curie Individual Fellowship
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2576. doi:
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    • Get Citation

      C Bellmann, GS Rubin, SA Kabanarou, AC Bird, FW Fitzke; Fundus Autofluorescence Imaging Compared With Different Confocal Scanning Laser Ophthalmoscopes . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2576.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To analyse and compare results of fundus autofluorescence (FAF) imaging using different confocal scanning laser ophthalmoscopes (cSLO). Methods: 8 eyes of 5 normal volunteers and 11 eyes of 7 patients with different retinal diseases (age-related macular degeneration, macular dystrophy, central serous retinopathy) were examined. On each patient FAF images were recorded with the Heidelberg Retina Angiograph (HRA), the Rodenstock SLO (RcSLO) and the Zeiss Prototype SM 30-4024 (ZcSLO). For excitation an Argon laser (488nm) was used (Barrier filter: HRA 500nm; RcSLO 515nm; ZcSLO 521nm). 32 FAF images were aligned and averaged using the same software for all cSLOs. Intensity of FAF was measured and compared using gray scale arbitrary units. Results: The mean age of all subjects was 55.5±21.4 SD years. The gray scale distribution of FAF throughout the posterior pole was measured in all subjects on all cSLOs. The gray scale range (in arbitrary units) averaged across all eyes was 66.2±28.4 SD for the HRA, 54.7±14.2 SD for the ZcSLO and 19.5±7.5 SD for the RcSLO. The difference was statistically significant (repeated measures ANOVA; p<0.0001). Post hoc comparisons indicated that gray scale values were significantly higher (p<0.01) for the HRA and the ZcSLO than for the RcSLO. However, there was no significant difference between the HRA and the ZcSLO. In normal subjects we found no significant difference in FAF distribution of maximum gray scale levels between the areas nasal and temporal to the fovea for any cSLO (HRA p=0.49; RcSLO p=0.18; ZcSLO p=0.67). Conclusion: All cSLOs allow clinical useful FAF imaging. However, the greatest range of gray scale levels were found in the HRA images and the lowest in the RcSLO images with no statistical difference between the HRA and the ZcSLO.

Keywords: 432 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 430 imaging/image analysis: clinical • 460 macula/fovea 
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