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L Cabay, F Willermain, L Lespagnard, B Nowak, J-L Dargent, A Maho, Y Witta, T Velu, L Casper-Velu, C Bruyns; CXCR4 Is Expressed on Vitreoretinal Membranes . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2614.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To investigate if the chemokine receptor CXCR4 is expressed in vitreoretinal membranes from Proliferative vitreoretinopathy (PVR) and macular pucker (MP). Methods:Membranes (3 PVR and 3 puckers) were surgically removed and immunohistochemistry with antibody recognising CXCR4, cytokeratin (CK), smooth muscle actin (SMA) and GFAP were performed. Results:: Membranes from PVR displayed a higher cellular density compared with MP. CXCR4, CK, SMA and GFAP were expressed in both types of membranes, but with variable intensities from one to another specimens. Conclusion:We show that CXCR4 is expressed in vitreoretinal membranes.. Further experiments need to be performed to test if CXCR4 (and other chemokine receptors) is implicated in vitreoretinal membrane formation.
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