December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Disruption of the Taurine Transporter Gene (taut) Leads to Retinal Degeneration in Mice
Author Affiliations & Notes
  • A Huth
    Retinal Electrodiagnostics Research Group Dept of Ophthalmology II Univ of Tuebingen Tuebingen Germany
  • MW Seeliger
    Retinal Electrodiagnostics Research Group Dept of Ophthalmology II Univ of Tuebingen Tuebingen Germany
  • B Heller-Stilb
    Dept of Gastroenterology Hepatology and Infectiology
    Univ of Duesseldorf Duesseldorf Germany
  • C van Roeyen
    Dept of Gastroenterology Hepatology and Infectiology
    Univ of Duesseldorf Duesseldorf Germany
  • K Rascher
    Dept of Anatomy
    Univ of Duesseldorf Duesseldorf Germany
  • HG Hartwig
    Dept of Anatomy
    Univ of Duesseldorf Duesseldorf Germany
  • U Warskulat
    Dept of Gastroenterology Hepatology and Infectiology
    Univ of Duesseldorf Duesseldorf Germany
  • D Häussinger
    Dept of Gastroenterology Hepatology and Infectiology
    Univ of Duesseldorf Duesseldorf Germany
  • Footnotes
    Commercial Relationships   A. Huth, None; M.W. Seeliger, None; B. Heller-Stilb, None; C. van Roeyen, None; K. Rascher, None; H.G. Hartwig, None; U. Warskulat, None; D. Häussinger, None. Grant Identification: Support: DFG (SFB 430 C2, SFB 575, Se837/1), Fritz-Thyssen-Foundation
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2711. doi:
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    • Get Citation

      A Huth, MW Seeliger, B Heller-Stilb, C van Roeyen, K Rascher, HG Hartwig, U Warskulat, D Häussinger; Disruption of the Taurine Transporter Gene (taut) Leads to Retinal Degeneration in Mice . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2711.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Taurine is involved in cell volume homeostasis, antioxidant defense, protein stabilization and stress responses. High levels of intracellular taurine are maintained by a Na+-dependent taurine transporter (TAUT) in the plasma membrane. Here, we studied the effects of a disrupted gene coding for the taurine transporter on the retina in taut-/- mice. Methods: TAUT knockout mice were generated by targeted disruption. Retinal morphology was assessed at different ages by standard histological methods and TUNEL staining. Ganzfeld ERGs were obtained from normal and taut-/- mice using single flash and flicker stimuli under both scotopic and photopic conditions. Results: Taut -/- mice show markedly decreased taurine levels in a variety of tissues, reduced fertility and loss of vision due to severe retinal degeneration, which involves apoptosis. ERG responses were reduced from early on, but recordable upto about 4 weeks postnatally. Conclusion: The results identify the taurine transporter as an important factor for the maintenance of the morphological and functional integrity of the retina.

Keywords: 595 taurine • 316 animal model • 396 electroretinography: non-clinical 
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