December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Drusen Result of Genetic Contraint
Author Affiliations & Notes
  • JC Dawson
    Ophthalmology University of Florida Gainesville FL
  • WW Dawson
    Ophthalmology University of Florida Gainesville FL
  • J Gonzalez-Martinez
    Caribbean Primate Research Center University of Puerto Rico San Juan Puerto Rico
  • JF Rodriguez
    Caribbean Primate Research Center University of Puerto Rico San Juan Puerto Rico
  • EN Kraiselburd
    Caribbean Primate Research Center University of Puerto Rico San Juan Puerto Rico
  • Footnotes
    Commercial Relationships   J.C. Dawson, None; W.W. Dawson, None; J. Gonzalez-Martinez, None; J.F. Rodriguez, None; E.N. Kraiselburd, None. Grant Identification: Unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 2784. doi:
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      JC Dawson, WW Dawson, J Gonzalez-Martinez, JF Rodriguez, EN Kraiselburd; Drusen Result of Genetic Contraint . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2784.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:Drusen are a major indicator of outer retina-pigment epithelium ageing and degenerative disease. Several classes of drusen have been reported (Dawson et al. Doc. Ophthal., 1989; Hope et al. BJO, 1992) in the older members of a closed (ca. 60 years) colony of rhesus monkeys (n=∼1500) at Univ. PR. The colony usually contains 10-20 social groups (matrilines) which structure breeding. Environment and nutrition are tightly controlled. Older group M (n= ∼200) fundi were sampled (1993-94) randomly, early in a period of isolation from the main colony. Drusen load was compared in a second sample after 7 years isolation. Methods:Samples ≷ 7 years of age were n=15 (1993- 1994) and n=32 (2001). Pupils were dilated for direct ophthalmoscope examination. Perimacular and macular drusen grades were I (normal), II<5, III=5-10, IV≷10. Results:Drusen ranged from granular, small-punctate, to large with diffuse edges and confluence. Drusen were more numerous in the macula and were rarely monocular. Scoring was based on the most "advanced" eye per individual. In 1994, 4/15 (26%) of the sample exhibited drusen. Thirteen percent were grade II and 13% grade III. In 2001 21/32 (66%) exhibited drusen. Thirty-seven percent were grade II, 15.6% III, 12.5% IV. Incidence difference between the samples is indicated by chi2=61.5, p<0.001. Confluent and soft drusen were limited to grades III, IV. Distribution of "grades" with age, 8 to 21(28-74 human years) did not show strong trends. Incidence was strongly related to age. Conclusion:Incidence of drusen in in-bred primates is remarkably dependent on genetic diversity.

Keywords: 308 age-related macular degeneration • 309 aging • 316 animal model 
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