December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Intraoperative 5-Fluorouracil in Endonasal Laser Dacryocystorhinostomy
Author Affiliations & Notes
  • K Bakri
    Otorhinolaryngology
    University of Nottingham Nottingham United Kingdom
  • NS Jones
    Otorhinolaryngology
    University of Nottingham Nottingham United Kingdom
  • R Downes
    Ophthalmology
    University of Nottingham Nottingham United Kingdom
  • A Sadiq
    Ophthalmology
    University of Nottingham Nottingham United Kingdom
  • Footnotes
    Commercial Relationships   K. Bakri, None; N.S. Jones, None; R. Downes, None; A. Sadiq, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3022. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      K Bakri, NS Jones, R Downes, A Sadiq; Intraoperative 5-Fluorouracil in Endonasal Laser Dacryocystorhinostomy . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3022.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: Although endonasal laser dacryocystorhinostomy (ELDCR) offers many advantages over conventional techniques, the incidence of post-operative scarring leading to occlusion of the rhinostomy is more common than conventional surgery. The aim of this study was to investigate whether 5-fluorouracil (5-FU) applied to the rhinostomy site intraoperatively has an effect on the outcome of the procedure. Participants: 155 consecutive patients (201 procedures) were randomly allocated to 2 groups - a control group and a 5-FU group. The choice of treatment was masked from both patients and investigators. Methods: ELDCR was performed on all patients. A pledget soaked in either normal saline or 0.5mg/ml 5-FU was applied to the rhinostomy site for 5 minutes at the time of surgery. Patients were followed up for 12 months and their symptoms assessed at each visit. Results: ELDCR procedures performed with topical application of 5-fluorouracil to the rhinostomy site showed a success rate of 76% at 12 months. ELDCR procedures performed with topical application of 0.9% saline showed a success rate of 63% at 12 months. This was not statistically significant (p≷0.05, Chi-squared test). Conclusion: The topical application of 5FU failed to increase the patency rates in ELDCR. Given the overall success rate at 12 months (58% if non-attenders counted as failures, 76% if regarded as successes), the place of ELDCR can no longer be advocated as the procedure of choice except in anticoagulated patients as endoscopic DCR done with mucosal flaps or external DCR gives superior results.

Keywords: 454 laser • 452 lacrimal gland 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×