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H Gill, EH Black, GJ Gladstone, H Budev; Histopathologic Correlates of Nerve Distribution in Upper Eyelid Skin . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3027.
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Purpose: It has been noted subjectively, especially during local anesthetic administration, that the sensitivity of the upper eyelid is greater medially than laterally. The purpose of our study is to find out whether there is a correlation between this subjective finding and the actual number of nerve endings in the upper eyelid skin. Methods: We evaluated upper eyelid skin that was already being removed for blepharoplasty procedures. Vertical sections of skin from the medial and lateral portion of 11 specimens were prepared and stained with S100 stain. The number of nerve endings were counted in both sections of each specimen. Results: The average number of nerve endings in the medial sections was 8.0 . In the lateral sections, the average number of nerve endings was 8.81. The results showed a mean difference of 0.818 and a p value of 0.29. There was no statistically significant difference between the number of nerve endings in the medial and lateral sections. Conclusion: There does not seem to be a significant difference between the number of nerve endings in the medial upper eyelid when compared to the lateral upper eyelid. These results do not explain the subjective finding of greater sensitivity in the medial upper eyelid.
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