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SA Hodson, F Miller, J Miller, C Routledge, C-H Tran; Sub-structures of Electric Fields in Mouse Tear Film . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3135.
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Purpose:To investigate the distribution of ion exchanging macromolecules throughout the murine tear film Methods:Microelectrodes were advanced through the full thickness of the murine tear film from the air to the underlying epithithelium in steps of 0.1 microns and electrical potentials collected Results:The anterior and central tear film had spontaneous electrical potentials which were uniform in any one preparation but varied between +4 and +12 mV in different preparations. Just before the microelectrode entered the epithelium, the p.d went negative for about 0.7 microns Conclusion:The tear film is filled throughout its thickness with anion exchanging macromolecules. In a peri-epithelial region approximating to the location of the epithelial glycocalyx, is located a region of cation exchanging macromolecules. It is suggested that this electrical inversion may provide sufficient adhesive power to maintain tear film mucins on the corneal epithelium
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