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CA Cox, JT Flynn, Y Sawada, AJ W Huang; Impression Cytology used to Diagnose Benign Hereditary Intraepithelial Dyskeratosis . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3174.
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Purpose: To evaluate the cytological features of Benign Hereditary Intraepithelial Dyskeratosis (BHID). Methods: Two non-related patients were diagnosed with BHID clinically. Pathology specimens wereexcised from case 1 at the age of three months. Routine impression cytology was taken from the bulbar conjunctiva at the age of fourteen years in case 2. Results: Minimal conjunctival epithelial pathology was identified in the excised specimen from case 1. The specimen was initially diagnosed as normal conjunctiva, but further examination revealed dyskeratotic features on the conjunctiva. The impression cytology specimen obtained from case 2 revealed the absence of conjunctival goblet cells, keratinization and dyskeratosis, consistent with squamous metaplasia. Conclusion: BHID shows classical features of conjunctival squamous metaplasia, and it can be diagnosed by the use of impression cytology, thereby avoiding the need for surgical biopsy and related complications.
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