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MT Kralinger, J Troger, J Hinterhoelzl, R Fischer-Colbrie, GF Kieselbach; GAIPIRRH Upregulation in the Aqueous Humor . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3242.
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Purpose: GAIPIRRH probably represents a novel neuropeptide and is derived from NESP55 by proteolytic processing. NESP55 constitutes a member of the chromogranin family and GAIPIRRH seems to represent the dominant form of NESP55 in various tissues. To investigate whether GAIPIRRH is present in the eye was goal of the present study. Methods: Aqueous humor (20-200µl) was aspirated in thirteen patients. Seven of the patients underwent cataract surgery, while three patients were operated for rhegmatogenous retinal detachment and three for proliferative vitreoretinopathy. 10µl were used to measure the concentration of GAIPIRRH by radioimmunoassay. Results: GAIPIRRH could not be detected in the aqueous of cataractous eyes, while it was present in two of three eyes treated for retinal detachment and in all eyes treated for proliferative vitreoretinopathy. The highest levels were measured in case of PVR: 13.9-154.1fmol/10µl. In case of retinal detachment GAIPIRRH expression decreased to 14.4 and 40.5fmol/10µl. Conclusion: Our results demonstrate the presence of GAIPIRRH in the aqueous humor of patients with retinal detachment and especially in patients with PVR, whereas the peptide was below detection in uninflamed eyes (cataracts). These results are similar to those found in respect to upregulation of the peptides substance P, vasoactive intestinal polypeptide and calcitonin gene-related peptide in PVR. The elevation most likely is due to release from the iris/ciliary body complex subsequent to sensitization of nerve fibres.
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