December 2002
Volume 43, Issue 13
ARVO Annual Meeting Abstract  |   December 2002
Effect Of Dopamine D1 Antagonist On Ciliary Blood Flow And Aqueous Flow In Rabbits
Author Affiliations & Notes
  • JW Kiel
    Ophthalmology Univ of TX Hlth Science Center San Antonio TX
  • HA Reitsamer
    Physiology Univ of Vienna Medical School Vienna Austria
  • A Doelemeyer
    Novartis Ophthalmics Basel Switzerland
  • Footnotes
    Commercial Relationships   J.W. Kiel, None; H.A. Reitsamer, None; A. Doelemeyer, Novartis Ophthalmics E. Grant Identification: NIH EY09702, FWF J1866-MED, RPB
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3275. doi:
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      JW Kiel, HA Reitsamer, A Doelemeyer; Effect Of Dopamine D1 Antagonist On Ciliary Blood Flow And Aqueous Flow In Rabbits . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3275.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: In a previous study, we found that intravenous infusion of dopamine causes dose-dependent, parallel changes in ciliary blood flow and aqueous flow, with vasodilation and increased aqueous flow occurring at a low dose and vasoconstriction and decreased aqueous flow occurring at a higher dose. In the present study, we sought to determine the extent of endogenous dopaminergic D1 receptor activation. Methods: Two groups of anesthetized rabbits were instrumented with an ear artery cannula to measure mean arterial pressure (MAP), a vitreous cannula to measure IOP, and a catheter in the orbital venous sinus to measure orbital venous pressure (OVP). In one group (n=12), aqueous flow was measured by fluorophotometry. In the other group (n=7), ciliary blood flow was measured by laser Doppler flowmetry. Measurements were performed before and after giving the D1 antagonist SCH-23390 (250 µ g/kg, iv). Results:  

SCH-23390 did not alter baseline ciliary blood flow or the ciliary pressure-flow relationship. Conclusion: The anesthetized rabbit eye receives tonic dopaminergic input. Loss of D1 activation causes increased aqueous production, and slight decreases in orbital venous pressure and IOP.

Keywords: 389 dopamine • 348 ciliary body • 444 intraocular pressure 

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