December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Quantification of Argon-Laser-induced damage of the blood-retinal-barrier: In vivo measurement of vitreal molecular changes by means of Dynamic Light Scattering (DLS)
Author Affiliations & Notes
  • SB Pressmar
    Ophthalmology Univ Eye Clinic Hamburg Germany
  • J Carstens
    Ophthalmology Univ Eye Clinic Hamburg Germany
  • V Sturm
    Ophthalmology Univ Eye Clinic Hamburg Germany
  • E Pörksen
    Ophthalmology Univ Eye Clinic Hamburg Germany
  • N Schmitz
    Ophthalmology Univ Eye Clinic Hamburg Germany
  • G Richard
    Ophthalmology Univ Eye Clinic Hamburg Germany
  • F Fankhauser
    Ophthalmology Univ Eye Clinic Hamburg Germany
  • Footnotes
    Commercial Relationships   S.B. Pressmar, None; J. Carstens, None; V. Sturm, None; E. Pörksen, None; N. Schmitz, None; G. Richard, None; F. Fankhauser, None. Grant Identification: none
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3298. doi:
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    • Get Citation

      SB Pressmar, J Carstens, V Sturm, E Pörksen, N Schmitz, G Richard, F Fankhauser; Quantification of Argon-Laser-induced damage of the blood-retinal-barrier: In vivo measurement of vitreal molecular changes by means of Dynamic Light Scattering (DLS) . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3298.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Dynamic Light Scattering (DLS) is an established non-invasive method for in vivo measurement of protein changes within the vitreous. In this study we set to quantify molecular changes of the protein structure of the vitreous before and after Argon-Laser-retinopexy. Methods: A collective of 10 patients with non-proliferative diabetic retinopathy grade 1 - 3, who never had laser treatment of the retina before, was examined with DLS. Measurements were performed before, immediately after, as well as at day 1, 5, 14 and week 4, 6, 8 after laser treatment. Results: Immediately after laser treatment there was an inflow of plasma proteins into the vitreous indicated by a shift of the autocorrelation functions towards higher frequencies. During the follow-up period the autocorrelation functions showed a trend to return to the preoperative state within an interindividually variable time-interval of 4 to 8 weeks. Conclusion: In this study we have demonstrated, that DLS is a suitable tool for detecting the breakdown of the blood-retinal-barrier after Argon-Laser-retinopexy. Due to the limited number of patients and a marked interindividual variability in this pilot-study the observed trends did not reach statistically significant levels, which are currently under investigation at a larger collective.

Keywords: 554 retina • 454 laser • 388 diabetic retinopathy 
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