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D Faingold, C Hudson, J Flanagan, R Rawji, K Guan, Y Buys, G Trope; Assessment Of The Impact Of Dorzolamide On Retinal Arteriole Blood Flow In Normal Eyes Using The Canon Laser Blood Flowmeter . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3311.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To evaluate the effect of Dorzolamide on the retinal blood flow of normal eyes using the Canon Laser Blood Flowmeter (CLBF) model 100. Methods:The CLBF simultaneously determines centerline velocity (mm/sec) and diameter (um) of the retinal arterioles and venules. It calculates the flow in ul/min based on the Poiseuille principle. Twenty eyes of 10 clinically normal subjects were studied. Measurements were taken of the infero-temporal arterioles approximately 1 disc diameter from the edge of the optic nerve. The eyes of each subject were divided randomly into two groups; 10 eyes received topical Dorzolamide and the second eye a placebo. CLBF and intraocular pressure measurements were made before and after drug administration. Statistical analysis between baseline and following administration of drug / placebo were calculated using paired t-tests. Results:Dorzolamide reduced intraocular pressure from 16.22.39 to 13.93.84 (mmHg) in the treated group but the decrease was not statistically significant (p≷0.05). There was no significant reduction in the blood flow parameters, however, all parameters measured in the Dorzolamide treated eyes showed a slight decrease compared with the baseline conditions: diameter 113.216.04 to 108.4817.27(um),blood velocity 35.047.49 to 32.859.20 (mm/sec) and blood flow 11.094.27 to 9.543.78 (ul/min) Conclusion: These results indicates that one topical application of Dorzolamide in healthy subjects had no statistically significant impact on retinal arteriole diameter, blood velocity and blood flow measured by the CLBF
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