December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Assessment Of The Impact Of Dorzolamide On Retinal Arteriole Blood Flow In Normal Eyes Using The Canon Laser Blood Flowmeter
Author Affiliations & Notes
  • D Faingold
    Ophthalmology University of Toronto Toronto Western Hospital Toronto ON Canada
  • C Hudson
    Toronto ON Canada
  • J Flanagan
    Toronto ON Canada
  • R Rawji
    Toronto ON Canada
  • K Guan
    Toronto ON Canada
  • Y Buys
    Toronto ON Canada
  • G Trope
    Toronto ON Canada
  • Footnotes
    Commercial Relationships   D. Faingold, None; C. Hudson , None; J. Flanagan , None; R. Rawji , None; K. Guan , None; Y. Buys , None; G. Trope , None. Grant Identification: none
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 3311. doi:
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    • Get Citation

      D Faingold, C Hudson, J Flanagan, R Rawji, K Guan, Y Buys, G Trope; Assessment Of The Impact Of Dorzolamide On Retinal Arteriole Blood Flow In Normal Eyes Using The Canon Laser Blood Flowmeter . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3311.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To evaluate the effect of Dorzolamide on the retinal blood flow of normal eyes using the Canon Laser Blood Flowmeter (CLBF) model 100. Methods:The CLBF simultaneously determines centerline velocity (mm/sec) and diameter (um) of the retinal arterioles and venules. It calculates the flow in ul/min based on the Poiseuille principle. Twenty eyes of 10 clinically normal subjects were studied. Measurements were taken of the infero-temporal arterioles approximately 1 disc diameter from the edge of the optic nerve. The eyes of each subject were divided randomly into two groups; 10 eyes received topical Dorzolamide and the second eye a placebo. CLBF and intraocular pressure measurements were made before and after drug administration. Statistical analysis between baseline and following administration of drug / placebo were calculated using paired t-tests. Results:Dorzolamide reduced intraocular pressure from 16.22.39 to 13.93.84 (mmHg) in the treated group but the decrease was not statistically significant (p≷0.05). There was no significant reduction in the blood flow parameters, however, all parameters measured in the Dorzolamide treated eyes showed a slight decrease compared with the baseline conditions: diameter 113.216.04 to 108.4817.27(um),blood velocity 35.047.49 to 32.859.20 (mm/sec) and blood flow 11.094.27 to 9.543.78 (ul/min) Conclusion: These results indicates that one topical application of Dorzolamide in healthy subjects had no statistically significant impact on retinal arteriole diameter, blood velocity and blood flow measured by the CLBF

Keywords: 514 pharmacology • 554 retina • 444 intraocular pressure 
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