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Y Sun, X Wu, X Zhang, X Xu, Y Wu; The Oscillatory Potentials and Fluorescein Angiographic Changes in Diabetic Retinopathy . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3477.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the oscillatory potentials(OPs) in different morphological stages of diabetic retinopathy(DR) under fundus fluorescein angiography(FA), so as to provide functional information for the follow-up and treatment of DR. Methods: 49 diabetic patients, 89 eyes were selected and divided into 4 groups by FA: without changes(group 1), with changes but without nonperfusion area or neovascular leakage(group 2), with nonperfusion area but without neovasucular leakage(group 3), with neovascular leakage but without vitreous haemorrhage or retinal detachment(group 4). All the eyes and 43 control eyes underwent OPs recording according to the protocol of International Society for Clinical Electrophysiology of Vision(ISCEV). Results: The summed amplitude of OPs reduced in group 2 compared with control. The amplitude of OP2 reduced in group 1 and reduced further in group 2. The summed amplitude of OPs and amplitudes of its wavelets(OP1, OP2, OP3, OP4) in group 3 reduced compared with group 2 and there was no difference of these indexes between group 3 and 4. Conclusion: The amplitude of OP2 is more sensitive than FA and the summed amplitude of OPs in DR. The retinal dysfunction or damage degree of vascular circulation in nonperfusion stage is nearly the same as neovascular formation stage. Nonperfusion area may be treated as another vital sign as neovascular formation in DR process and this can provide functional evidence for photocoagulation in this stage.
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