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RM Romero, A Rodriguez, I Yeshurun, JL Guerrero-Naranjo, L De-Barcia, H Quiroz-Mercado; Evaluation of Subretinal Endoscopic Photocoagulation with 532nm Laser in Pigmented Rabbit Eyes . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3506.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate thermal damage to the retinal pigment epithelium (RPE) and choriocapillaris with different laser energies, delivered with a high-resolution endoscope (HRE) after viscoelastic-induced retinal detachment on pigmented rabbit eyes. Methods: Eyes of pigmented rabbits were used to perform a pars-plana vitrectomy, posterior hyaloid removal, subretinal injection of sodium hyaluronate (SH) through a small retinotomy, creation of a dome-shaped retinal detachment with the SH bubble, and delivery of 532nm laser using a HRE. Three different energies were used (50mW, 100mW and 200mW) for 0.2 seconds, 1 mm away from the RPE. Eyes were then studied using standard histologic techniques. Results: Six eyes of six rabbits were used. Energies of 100 and 200 mW produced whitening of the RPE without bleeding. Applying 50 mW produced gray burns. Histologic evaluation showed RPE localized damage without disruption of choroidal architecture and complete preservation of retinal structures. Proliferative changes were not observed. Conclusion: Subretinal 532nm laser burns delivered by HRE (energies ranging from 50 to 200 mW) preserve retinal structures and produce minimal damage to RPE and choroid in pigmented rabbit eyes.
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