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S Bakalian, WE S Connolly, AL Caissie, PM Ozdal, J Burnier, MN Burnier; Anterior Lens Capsule Thickness in Diabetic and Non-diabetic Patients . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3592.
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Purpose: Diabetes has been shown to affect the thickness of the basement membrane in various human tissues and organs . The purpose of this study is to determine whether diabetes can cause thickening of the anterior lens capsule basement membrane (ACBM). Methods: In this prospective randomized study, anterior lens capsule specimens were collected from phaco-emulsification cataract surgeries, performed by the same surgeon using the same equipment and techniques. Twenty-four lens capsule specimens of diabetic patients (DP) and 48 of non-diabetic patients (NDP) were formalin-fixed, paraffin-embedded and stained with H&E and periodic acid-Schiff (PAS). The cases were reviewed under a light microscope at 40x magnification. The ACBM thickness was measured, in units (u), using a Carl-Zeiss 444034 eyepiece. The capsule thickness measurements were compared between the DP and NDP. DP and NDP were further divided into four groups according to age; group one (G1) <55, group 2 (G2) 55-65, group 3 (G3) 65-75, and group 4 (G4) ≷75 years old. DP were divided into three groups according to duration of the disease, D1 <5 years, D2 5-10 years, and D3 ≷10 years. Statistical analysis was performed using the student t-test. Results: The mean (M) age was 71.7 for DP and 73.9 for NDP. The M thickness of the ACBM for DP was 12.1u, ranging from 10 to 14u with SD=1.26. The M thickness of the ACBM for NDP was 9.3u, ranging from 7 to12u with SD=0.97. There was a statistically significant difference (p<0.001) in the thickness of ACBM between DP and NDP. In both DP and NDP, the ACBM thickness increased with patient age. For G1 the M thickness of ACBM was 11.5u for DP and 7.6u for NDP. For G2 the M thickness of ACBM was 11.6u for DP and 9.3u for NDP. For G3 the M thickness of ACBM was 12u for DP and 8.9u for NDP. For G4 the M thickness of ACBM was 12.8u for DP and 9.76u for NDP. It was found that ACBM thickness increased with the duration of the disease. The M thickness of ACBM was as follows: for D1 M=11.4u; for D2 M=11.7u; and for D3 M=12.6u. Conclusion: To the best of our knowledge this is the first study proving that the ACBM is significantly thicker in DP than in NDP and the thickness of ACBM in DP correlates with the age of the patient and the duration of the disease.
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