Purchase this article with an account.
AM Leys, MJ Leys, L Postelmans, B Pasteels, B Snyers, J-J De Laey, M Quaranta, M Mauget-Faÿsse; Photodynamic Therapy With Verteporfin for Choroidal Neovascularization in Inflammatory Disorders . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3970.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate photodynamic therapy (PDT) with verteporfin in subfoveal choroidal neovascularization associated with inflammatory disorders. Methods: We reviewed visual acuity (VA) and fluorescein angiography in 21 patients, 22 eyes, 9 - 74 years (mean 34) treated with PDT. Average follow up was 10 mo (3 - 20). We identified toxoplasmosis related CNV in 3, histoplasmosis (OHS) in 4, punctate inner choroidopathy (PIC) or multifocal choroiditis (MC) in 15 eyes. Five patients had prior thermal laser, six received PO steroids, two had thermal laser of the partially regressed CNV after PDT. One had surgical removal of CNV before and one after PDT. PDT was administered on 1-6 visits (mean 1.7). Results: VA in toxo related CNV was 20/170 on average (range 20/100-20/200) prior to PDT and 20/100 (20/50-20/160) after PDT. CNV remained inactive in the 2 eyes with improved VA. PIC/MFC related CNV-eyes with spherical equivalent between (-0.75 and -7D) had mean VA of 20/80 (20/25-20/200) prior to PDT and 20/40 (20/20-20/200) following 1-6 treatments. The maculopathy became inactive in 12 eyes. Three OHS eyes required 1 PDT with additional laser /submacular surgery to stabilize. Average VA improved from 20/125 (20/30-20/400) to 20/85 (20/20-20/200). In one eye CNV and VA stabilized after 2 PDT. Conclusion: VA improved in 17, and stabilized in 2 eyes. Three eyes lost 1-3 lines.Younger myopic eyes retained better vision after fewer treatments.
This PDF is available to Subscribers Only