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HD Jampel, J Bacharach, LG Wohl, W-P SheuLatanoprost vs Unoprostone Study Group; Comparison Of Latanoprost And Unoprostone In Subjects With Elevated Intraocular Pressure . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4063.
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Purpose: To compare the intraocular pressure (IOP) lowering effect and safety profile of latanoprost 0.005% once daily and unoprostone 0.15% twice daily in patients with open-angle glaucoma or ocular hypertension. Methods: Previously treated patients (n=161) with IOP ≷ 25 mm Hg after a washout period were randomized to receive either latanoprost 0.005% once daily in the evening or unoprostone 0.15% twice a day in an eight week, investigator-masked, randomized, parallel group, multicenter trial. IOP was measured at 8 am, 12 noon, and 4 pm at baseline and after 8 weeks of treatment. The main outcome measure was the change in the mean of the IOPs measured at 8 am, 12 noon, and 4 pm between the untreated baseline and after 8 weeks of treatment. Results: The change in the mean IOP for latanoprost of -7.2 + 3.9 mm Hg (from 25.3 + 2.8 mm Hg at baseline to 18.2 + 2.8 mm Hg at 8 weeks) was greater than that of unoprostone, which was 3.9 + 2.6 mm Hg (from 25.5 + 3.3 mm Hg at baseline to 21.6 + 4.0 mm Hg at 8 weeks), p = 0.000. Both agents were safe and well tolerated. Conclusion: Over an eight-week period, latanoprost 0.005% once daily lowers IOP more than unoprostone 0.15% twice daily in patients with elevated IOP.
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