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RL Stamper, OC Ong; Intraocular Pressure Lowering Effect With Substitution Of Bimatoprost For Latanoprost . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4101.
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Purpose:To evaluate the intraocular pressure (IOP) lowering effect when bimatoprost is substituted for latanoprost in patients with uncontrolled glaucoma. Methods:This is a retrospective noncomparative study based on the review of the medical records of 40 consecutive patients with uncontrolled glaucoma in whom bimatoprost was substituted for latanoprost. The right eye was randomly chosen for analysis of data when both eyes were treated. In the 7 patients that had only one eye treated, only the treated eye was included in the analysis. Four patients in whom bimatoprost was substituted but discontinued after less than 4 weeks of follow up due to intolerance to side effects were not included in this group of 40 patients. These side effects included burning and irritation (2 patients), hyperemia (1 patient), and headache (1 patient). Results:IOP lowering of 3 mm Hg or more (mean 4.5 mm Hg, range: 3 to 9 mm Hg) from the baseline IOP was found in 13 of 40 eyes in which bimatoprost was substituted for latanoprost. In the remaining 27 eyes, the reduction in the IOP after bimatoprost substitution was not significant (average: -0.6 mm Hg, range: -2.5 to +4.0 mm Hg). The average baseline IOP in the 13 eyes that responded to bimatoprost was 18.3 mm Hg (range: 13 to 23 mm Hg), and the average baseline IOP in the remaining 27 eyes was 17.0 mm Hg (range: 12.5 to 23 mm Hg). The follow up period of the patients in this study ranged from 6 weeks to 5 months. Some patients with initial response showed a tendency to return to baseline with time. Conclusion:This finding suggests that bimatoprost may contribute to an additional 3 mm Hg or more IOP lowering when substituted for latanoprost in about one third of patients.
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