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MC Banks, D Hoffman, H Syed, J Caprioli, S Law; Differences in Intraocular Pressure Response to Latanoprost Between Black and White Patients With Open Angle Glaucoma and Ocular Hypertension . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4104.
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Purpose: To compare the intraocular pressure (IOP) lowering effect of latanoprost (0.005%) between black and white patients. Methods: A retrospective chart review of patients who presented to the Glaucoma Division at the Jules Stein Eye Institute between 1996 and 2001 with open angle glaucoma or ocular hypertension was performed. Patients who were started on single drug therapy with latanoprost (0.005%) were identified. The eye with the higher pre-treatment IOP was enrolled. Demographic data and pre-treatment and post-treatment intraocular pressures were recorded. The IOP reduction was compared between black and white patients. Response to latanoprost treatment was defined as ≥ 30% IOP reduction and IOP ≤ 15 mmHg. Results: Ninety seven eyes of 66 white patients and 31 black patients with open angle glaucoma or ocular hypertension were identified. Mean follow-up was 9.9 ± 0.2 weeks. Mean pre-treatment intraocular pressures were not significantly different between white and black patients (20.44 ± 5.3 mmHg vs. 20.58 ± 4.6 mmHg, respectively). There was no significant difference between white and black patients for mean post-treatment IOP (14.23 ± 3.7 mmHg vs. 14.97 ± 4.2 mmHg), actual IOP reduction (6.21 ± 3.7 mmHg vs. 5.61 ± 2.7 mmHg), percent IOP reduction from baseline (29.08% ± 13.4% vs. 27.39% ± 10.5%), or percent of responders (38% vs. 45%). The power to detect an IOP difference of 3 mmHg between the two groups was 84%. Conclusion: In a clinical setting, retrospective review does not show a significant difference in intraocular pressure response to latanoprost (0.005%) in black patients compared to white patients.
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