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CN Cole, A Harris, C Pesavento, L Kagemann, CW Sheets, FH Orge; Test-Retest Reproducibility of Volumetric Flow Measurements with ATL Ultrasound in an In-vitro Model . Invest. Ophthalmol. Vis. Sci. 2002;43(13):4359.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To evaluate the test-retest reproducibility of ATL HDI-5000 CDI measurements of volumetric blood flowas compared to an in-vitro phantom flow model. Methods:A phantom flow model was constructed using agarose gel to mimic fatty soft tissue. 1.57mm and 2.36mm lumens were created in the gel. A UHDC flow system pumped blood mimicking fluid through each tube at three different rates. The ATL HDI-5000 measured the velocity and volumetric flow in the phantom model using cineloops (a cineloop is a rapidly acquired sequence of CDI images). A newly developed software package from ATL calculated both volumetric flow and velocity from the cineloops. Measurements were performed with the probe in four different positions: 1) 45° angle, parallel to the flow, 2) 45° angle, offset to the flow, 3) 75° angle, parallel to the flow, and 4) 75° angle, offset to the flow. The coefficient of variance was then calculated for each of the probe positions. Results:The average coefficients of variation for volumetric blood velocity were 6.6% and 9.2% in the 1.57mm and 2.36mm vessels, respectively. The average coefficients of variation for volumetric blood flow were 12.0% and 10.8% in the 1.57 mm and 2.36 mm vessels, respectively. Conclusion:The ATL HDI-5000 using the new cineloop software package presents with acceptable reproducibility data for the evaluation of volumetric blood flow in small vessels in the human eye.
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