July 2015
Volume 56, Issue 8
Free
Research Highlight  |   July 2015
Suprachoroidal Drug Delivery: Unique New Observations
Author Affiliations
  • Timothy W. Olsen
    Emory Eye Center Department of Ophthalmology, Emory University, Atlanta, Georgia, United States; tolsen@emory.edu
Investigative Ophthalmology & Visual Science July 2015, Vol.56, 4976. doi:10.1167/iovs.15-17391
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Timothy W. Olsen; Suprachoroidal Drug Delivery: Unique New Observations. Invest. Ophthalmol. Vis. Sci. 2015;56(8):4976. doi: 10.1167/iovs.15-17391.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Gu et al.1 use ultra-high resolution ocular coherence tomography (UHR-OCT) in the guinea pig eye model to evaluate suprachoroidal drug delivery using 10- to 20-μL injections of either saline, indocyanine green (ICG), or triamcinolone acetate (TA). The authors have an elegantly designed study that measures the cross-sectional area of the suprachoroidal space (SCS) using these various injections at time points from 5 minutes to 24 hours. Injections were delivered using a simple 30-gauge needle on a microsyringe. During the injection, too much volume led to reflux (20 μL). Suprachoroidal expansion was mostly noted near the site of injection with some diffusion into the SCS around the globe. For saline, most of the suprachoroidal volume normalized quickly (30 minutes). During the ICG injection, approximate 50% volume measure in the SCS occurred at around 1 to 2 hours and for TA, at approximately 6 hours with a much slower normalization and thus a potential for sustained delivery. The reported pharmacokinetics are consistent with our prior findings in the large pig model.2 Figure 9 from Gu et al.1 nicely illustrates both ICG and TA injections that are well visualized through transparent sclera as well as from the indirect view from inside the eye (Fig. 10). 
In summary, the excellent work by Gu et al. demonstrates sustained suprachoroidal delivery using a simple 30-gauge needle with favorable pharmacokinetics in the SCS via a small molecule suspension of a drug with low solubility (TA) that may have more ideal pharmacokinetic properties for delivery into the SCS. The transparent sclera in this model is truly unique and allows visualization of the drug in the target location. Drug delivery to the SCS is not without risk, and further safety studies are necessary; however, this small animal model nicely demonstrates the potential of suprachoroidal drug delivery. 
Acknowledgments
Supported in part by an unrestricted departmental grant from Research to Prevent Blindness, New York, New York, United States. 
References
Gu B, Liu J, Li X, Ma Q, Shen M, Cheng L. Real time monitoring of suprachoroidal space (SCS) following SCS injection using ultra-high resolution optical coherence tomography in guinea pig eyes. Invest Ophthalmol Vis Sci. 2015; 56: 3623–3634.
Olsen TW, Feng X, Wabner K, et al. Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment. Am J Ophthalmol. 2006; 142: 777–787.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×