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Sheila T. Angeles-Han, Courtney McCracken, Steven Yeh, Se Ryeong Jang, Kirsten Jenkins, Spencer Cope, John Bohnsack, Aimee Hersh, Susan D. Thompson, Sampath Prahalad; HLA Associations in a Cohort of Children With Juvenile Idiopathic Arthritis With and Without Uveitis. Invest. Ophthalmol. Vis. Sci. 2015;56(10):6043-6048. doi: 10.1167/iovs.15-17168.
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Juvenile idiopathic arthritis (JIA)–associated uveitis can lead to ocular complications and vision loss. Alleles HLA-DRB1*08, *11, and *13 are risk alleles for JIA, whereas HLA-DRB1*11 and *13 alleles increase uveitis susceptibility. We examined the association of common HLA-DRB1 alleles in children with JIA alone and JIA-associated uveitis.
High-resolution HLA-DRB1 genotyping was performed in 107 children with oligoarticular and polyarticular rheumatoid factor (RF) negative JIA and 373 non-Hispanic white controls. Children with JIA alone and JIA-associated uveitis were of similar race, ethnicity, sex, and age at arthritis diagnosis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.
There were 47 children with JIA-associated uveitis and 60 with JIA alone. Compared to controls, only children with JIA-associated uveitis had increased odds of carriage of HLA-DRB1*11 (OR, 2.2 95% [CI, 1.1–4.3], P = 0.023). There also was increased carriage of HLA-DRB1*08 and *13 (OR, 12.6 [95% CI, 2.0–77.8], P = 0.011). Compared to controls and children with JIA alone, those with JIA-associated uveitis had increased odds of carriage of HLA-DRB1*11 and *13 (OR, 9 [95% CI, 2.8–29.0], P < 0.0001 and OR, 8.6 [95% CI, 1.0–74.4], P = 0.042), respectively.
We report the novel finding that carriage of HLA-DRB1*11 and *13 appears to increase the risk of uveitis in children with JIA.
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