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Akihiro Ishibazawa, Taiji Nagaoka, Yoshiro Minami, Manabu Kitahara, Takanori Yamashita, Akitoshi Yoshida; Choroidal Thickness Evaluation Before and After Hemodialysis in Patients With and Without Diabetes. Invest. Ophthalmol. Vis. Sci. 2015;56(11):6534-6541. doi: 10.1167/iovs.15-16719.
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© ARVO (1962-2015); The Authors (2016-present)
We evaluated the effect of hemodialysis on the choroidal thickness in patients with and without diabetes who have end-stage kidney disease (ESKD).
Forty-one patients with ESKD were recruited and divided into two groups: those with ESKD due to diabetic nephropathy (DM group, 37 eyes of 20 patients) and those with nondiabetic ESKD (NDM group, 40 eyes of 21 patients). Using spectral-domain optical coherence tomography (SD-OCT), the subfoveal choroidal thickness (SCT) was measured before and after hemodialysis, and the change ratio (ΔSCT [%]) was calculated.
The SCT decreased in all eyes after hemodialysis. The ΔSCT value in the DM group (−12.6 ± 2.7%) was significantly (P = 0.00027) larger than that in the NDM group (−6.9 ± 2.3%). Moreover, the ΔSCT per body fluid removal (BFR [L]) in the DM group was significantly (P = 0.013) greater than in the NDM group. In the DM group, the mean ΔSCT in the eyes treated with panretinal photocoagulation (PRP; n = 19) was significantly (P = 0.035) larger than that in eyes not treated with PRP (n = 18). The relationship between the ΔSCT and BFR was not significant (R2 = 0.0038, P = 0.80) in the DM group but was significant (R2 = 0.54, P = 0.00013) in the NDM group.
The current results may reflect that systemic fluid accumulation has a greater effect on the diabetic choroid, probably due to damage to the choroidal vasculature, in patients with ESKD.
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