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Xin Liu, Jingmeng Chen, Zhe Liu, Jie Li, Ke Yao, Yalin Wu; Potential Therapeutic Agents Against Retinal Diseases Caused by Aberrant Metabolism of Retinoids. Invest. Ophthalmol. Vis. Sci. 2016;57(3):1017-1030. doi: 10.1167/iovs.15-18429.
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© ARVO (1962-2015); The Authors (2016-present)
The retinoid (visual) cycle is a complex enzymatic pathway that operates in the retina for the regeneration of 11-cis-retinal (11-cis-Ral), the inherent visual chromophore indispensable for vision. Deficiencies in the retinoid metabolism are involved in pathologic mechanisms of several forms of retinal diseases including age-related macular degeneration, Stargardt's disease, and Leber's congenital amaurosis, for which no effective cures presently exist. Nevertheless, the interference of abnormal retinoid metabolism with chemicals has been considered to be a promising strategy aimed at alleviating these retinal dysfunctions. Moreover, since gene therapy is gaining increasing importance in clinical practice, the modulation of key enzymes implicated with the retinoid cycle at a genetic level will hold great promise for the treatment of patients with degenerative diseases of the retina.
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