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Valeria Canto-Soler, Miguel Flores-Bellver, M. Natalia Vergara; Stem Cell Sources and Their Potential for the Treatment of Retinal Degenerations. Invest. Ophthalmol. Vis. Sci. 2016;57(5):ORSFd1-ORSFd9. doi: https://doi.org/10.1167/iovs.16-19127.
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© ARVO (1962-2015); The Authors (2016-present)
Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non–cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further in-depth analyses presented in the following chapters of this Special Issue.
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