April 2016
Volume 57, Issue 4
Open Access
Research Highlight  |   April 2016
Optical Coherence Tomography: A Potential Noninvasive Follow-up Tool in Multiple Sclerosis
Author Affiliations
Investigative Ophthalmology & Visual Science April 2016, Vol.57, 2318. doi:10.1167/iovs.16-19605
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      Rupesh Agrawal; Optical Coherence Tomography: A Potential Noninvasive Follow-up Tool in Multiple Sclerosis. Invest. Ophthalmol. Vis. Sci. 2016;57(4):2318. doi: 10.1167/iovs.16-19605.

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      © ARVO (1962-2015); The Authors (2016-present)

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Physicians have been struggling to objectively monitor the disease progression in multiple sclerosis (MS). There have been conflicting reports of significant reduction in retinal ganglion cell layer (RGC) and retinal nerve fiber layer (RNFL) loss in patients with MS.1,2 Loss of RGC and RNFL has been associated with disease-related visual deterioration and general disability and brain atrophy.3 The longitudinal study by Graham et al.4 about progressive loss of retinal ganglion cells and axons in fellow eyes of patients with relapsing–remitting MS with optic neuritis can provide substantial grounds for application of optical coherence tomography (OCT) as a noninvasive tool. This can be a very important ancillary tool for neurologists to monitor the progression of optic neuritis and should be explored in settings of multidisciplinary practice. As this noninvasive test is much easier to perform as compared to magnetic resonance imaging (MRI) and if it has value equal to or better than MRI, it should be added as an important follow-up test within the annual follow-up of patients with MS. However, further large-scale multicenter studies have to be conducted to establish this as an important optical biomarker in monitoring patients with MS. 
References
Sriram P, Graham SL, Wang C, Yiannikas C, Garrick R, Klistorner A. Transsynaptic retinal degeneration in optic neuropathies: optical coherence tomography study. Invest Ophthalmol Vis Sci. 2012; 53: 1271–1275.
Garcia-Martin E, Pueyo V, Martin J, et al. Progressive changes in the retinal nerve fiber layer in patients with multiple sclerosis. Eur J Ophthalmol. 2010; 20: 167–173.
Saidha S, Al-Louzi O, Ratchford JN, et al. Optical coherence tomography reflects brain atrophy in multiple sclerosis: a four-year study. Ann Neurol. 2015; 78: 801–813.
Graham EC, You Y, Yiannikas C, et al. Progressive loss of retinal ganglion cells and axons in nonoptic neuritis eyes in multiple sclerosis: a longitudinal optical coherence tomography study. Invest Ophthalmol Vis Sci. 2016; 57: 2311–2317.
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