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Huan Xu, Guohua Deng, Chunhui Jiang, Xiangmei Kong, Jian Yu, Xinghuai Sun; Microcirculatory Responses to Hyperoxia in Macular and Peripapillary Regions. Invest. Ophthalmol. Vis. Sci. 2016;57(10):4464-4468. doi: 10.1167/iovs.16-19603.
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To evaluate the hyperoxia response of the retinal vascular system in different parts of the fundus using optical coherence tomography (OCT) angiography.
Using an OCT angiography system and a split-spectrum amplitude decorrelation angiography (SSADA) algorithm, perfused vessel density at the macular and peripapillary regions was measured before and after breathing 80% oxygen in 10 healthy Chinese subjects. The repeatability of the hyperoxia response was also tested.
Hyperoxia provocation caused a significant decrease in retinal perfused vessel density in both the macular and peripapillary areas. The para- and perifoveal area had a mean reduction of 13.66% and 15.17%, respectively; these reductions were significantly greater than in the peripapillary area (9.52%; parafovea versus peripapillary, P = 0.023; perifovea versus peripapillary, P = 0.006). The coefficients of variation (CV), intraclass correlations (ICC), and Bland–Altman plots suggested strong repeatability of the hyperoxia response.
The optical coherence tomography system, in conjunction with the SSADA algorithm, recorded a significant reduction in retinal perfused vessel density after hyperoxia, and the reduction was greater in the macular area than in the peripapillary area.
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